Biological Complexity and the Dynamics of Life Processes (New Comprehensive Biochemistry)
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Control of metabolic networks under steady state conditions. Metabolic control theory. Biochemical systems theory.
Biochemistry: Versatile recycling in the cell
An example of the application of Metabolic control theory to a biological problem. Chapter 5. Compartmentalization of the living cell and thermodynamics of energy conversion. Thermodynamic properties of compartmentalized systems. Brief description of molecular events involved in energy coupling. Compartmentalization of the living cell and the kinetics and thermodynamics of coupled scalar and vectorial processes. Chapter 6.
The concept of robustness
Molecular crowding, transfer of information and channeling of molecules within supramolecular edifices. Molecular crowding. Statistical mechanics of ligand binding to supramolecular edifices. Statistical mechanics and catalysis within supramolecular edificis. Statistical mechanics of imprinting effects. Statistical mechanics of instruction transfer within supramolecular edifices.
Instruction, chaperones and prion proteins. Multienzyme complexes, instruction and energy transfer. Proteins at the lipid-water interface and instruction transfer to proteins. Information transfer between proteins and enzyme regulation. Channeling of reaction intermediates within multienzyme complexes.
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The different types of communication within multienzyme complexes. Chapter 7. Cell complexity, electrostatic partitioning of ions and bound enzyme reactions. Enzyme reactions in a homogeneous polyelectrolyte matrix.
Modelling biological systems - Wikipedia
Enzyme reactions in a complex heterogeneous polyelectrolyte matrix. An example of enzyme behaviour in a complex biological system: the kinetics of an enzyme bound to plant cell walls. Sensing, memorizing and conducting signals by polyelectrolyte-bound enzymes. Complexity of biological polyelectrolytes and the emergence of novel functions.
Chapter 8. Dynamics and mobility of supramolecular edifices in the living cell. Tubulin, actin and their supramolecular edifices. Dynamics and thermodynamics of tubulin and actin polymerization. Molecular motors and the statistical physics of muscle contraction. Dynamic state of supramolecular edifices in the living cell. Chapter 9.
Temporal organization of metabolic cycles and structural complexity: oscillations and chaos. Brief overview of the temporal organization of some metabolic processes. Minimum conditions required for the emergence of oscillations in a model metabolic cycle.
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Emergence of a temporal organization generated by compartmentalization and electric repulsion effects. Periodic and aperiodic oscillations generated by the complexity of the supramolecular edifices of the cell. ATP synthesis and active transport induced by periodic electric fields. Some functional advantages of complexity. Chapter Spatio-temporal organization during the early stages of development.
Positional information and the existence of gradients of morphogens during early development. The emergence of patterns and forms. Pattern formation and complexity. Evolution towards complexity. The need for a membrane. How to improve the efficiency of metabolic networks in homogeneous phase. The emergence and functional advantages of compartmentalization. Evolution of molecular crowding and the different types of information transfer.
Control of phenotypic expression by a negatively charged cell wall. Evolution of the cell structures associated with motion. The emergence of temporal organization as a consequence of supramolecular complexity. The emergence of multicellular organisms. Subject area s : RNA Development.
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